How to Source Brimonidine tartrate + Timolol maleate for Pharmaceutical Formulation

Brimonidine tartrate + Timolol maleate (Eye Drops, 0.2%+0.5%) is classified under Opthalmology. It is therapeutically aligned with reference brands such as Combigan (USA/EU). This guide highlights key sourcing factors buyers should consider when procuring high-quality Brimonidine tartrate + Timolol maleate for formulation, R&D, or bulk manufacturing.

Product Overview: Combigan is a fixed-dose combination ophthalmic solution that combines an α₂-adrenergic agonist (brimonidine) with a non-selective β-adrenergic blocker (timolol) to reduce elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension. Brimonidine decreases aqueous humour production and increases uveoscleral outflow, while timolol reduces aqueous humour formation.

1. Regulatory Compliance & Documentation

Ensure suppliers provide:

• ✔ Valid DMF (Drug Master File)
• ✔ COA (Certificate of Analysis) for each batch
• ✔ GMP, ISO, or ICH Q7 compliance certificates

2. Purity, Grade & Specification Matching

Brimonidine tartrate + Timolol maleate must meet exact grade and purity for your dosage form:

• ✔ USP / EP / JP grade verification
• ✔ Particle size distribution check
• ✔ Residual solvent and heavy metal limits

3. Supplier Reliability & Audit History

• ✔ Positive past audit reports
• ✔ Pharma client references
• ✔ Years of proven API manufacturing experience

4. Commercial Terms: Pricing, MOQ & Flexibility

• ✔ Transparent pricing
• ✔ Pilot batch MOQ flexibility
• ✔ Volume-based discounts

5. Lead Time, Inventory & Logistics

Typical lead time for Brimonidine tartrate + Timolol maleate is 4–6 weeks.

• ✔ Emergency dispatch options
• ✔ Regional warehousing
• ✔ Special storage if needed

6. Formulation Support

• ✔ Technical datasheets
• ✔ Sample availability
• ✔ Stability study support

Conclusion

Sourcing Brimonidine tartrate + Timolol maleate is more than procurement—it’s a strategic partnership. With its eye drops form and 0.2%+0.5% specification, choosing a compliant supplier ensures consistent quality and regulatory approval. Prioritize documentation, verify compatibility, and build relationships with transparent, reliable suppliers to secure long-term success.

Frequently Asked Questions For Sourcing of Brimonidine tartrate + Timolol maleate