How to Source Sulfadoxine + Pyrimethamine (SP) – tablets for Pharmaceutical Formulation

Sulfadoxine + Pyrimethamine (SP) – tablets (Tablet, 500 mg sulfadoxine + 25 mg pyrimethamine; 500 mg + 75 mg) is classified under Medical Aid. It is therapeutically aligned with reference brands such as Generic formulations. This guide highlights key sourcing factors buyers should consider when procuring high-quality Sulfadoxine + Pyrimethamine (SP) – tablets for formulation, R&D, or bulk manufacturing.

Product Overview: Sulfadoxine inhibits bacterial dihydropteroate synthase, while pyrimethamine blocks dihydrofolate reductase, disrupting folate synthesis in malaria parasites. This combination effectively kills Plasmodium falciparum, providing rapid malaria prophylaxis and treatment. Benefits include high efficacy, synergy against resistant strains, and simplified dosing in endemic regions.

1. Regulatory Compliance & Documentation

Ensure suppliers provide:

• ✔ Valid DMF (Drug Master File)
• ✔ COA (Certificate of Analysis) for each batch
• ✔ GMP, ISO, or ICH Q7 compliance certificates

2. Purity, Grade & Specification Matching

Sulfadoxine + Pyrimethamine (SP) – tablets must meet exact grade and purity for your dosage form:

• ✔ USP / EP / JP grade verification
• ✔ Particle size distribution check
• ✔ Residual solvent and heavy metal limits

3. Supplier Reliability & Audit History

• ✔ Positive past audit reports
• ✔ Pharma client references
• ✔ Years of proven API manufacturing experience

4. Commercial Terms: Pricing, MOQ & Flexibility

• ✔ Transparent pricing
• ✔ Pilot batch MOQ flexibility
• ✔ Volume-based discounts

5. Lead Time, Inventory & Logistics

Typical lead time for Sulfadoxine + Pyrimethamine (SP) – tablets is 4–6 weeks.

• ✔ Emergency dispatch options
• ✔ Regional warehousing
• ✔ Special storage if needed

6. Formulation Support

• ✔ Technical datasheets
• ✔ Sample availability
• ✔ Stability study support

Conclusion

Sourcing Sulfadoxine + Pyrimethamine (SP) – tablets is more than procurement—it’s a strategic partnership. With its tablet form and 500 mg sulfadoxine + 25 mg pyrimethamine; 500 mg + 75 mg specification, choosing a compliant supplier ensures consistent quality and regulatory approval. Prioritize documentation, verify compatibility, and build relationships with transparent, reliable suppliers to secure long-term success.

Frequently Asked Questions For Sourcing of Sulfadoxine + Pyrimethamine (SP) – tablets