Levoketoconazole Suppliers & Bulk Manufacturers
Available Forms: Tablets
Available Strengths: 150 mg ,300 mg
Reference Brands: Recorlev (USA)
Category:
Anti-fungal
Levoketoconazole is available in Tablets
and strengths such as 150 mg ,300 mg.
Sourced from GMP-certified and ISO-compliant manufacturers, this API meets
global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical
formulation and commercial manufacturing, Levoketoconazole is supplied in
bulk quantities with complete regulatory support including DMF, COA, and MSDS.
|
Technical Specifications & Supply Details
|
| Lead Time |
7 to 60 days (depending on batch size & schedule) |
| MOQ |
As per manufacturer’s batch size |
| COA |
Available with every batch |
| Regulatory Dossier / DMF |
Available upon request |
| Export Documentation |
FSC, COA, Manufacturing License, Product Permission |
| Standards |
IP, BP, USP |
| Certifications |
WHO-GMP, EU-GMP, USFDA (as applicable) |
Levoketoconazole can be exported to over 30 countries across Asia, Africa, Europe,
and Latin America. Flexible packaging, competitive pricing, and a verified supplier
network make Pharmatradz a trusted sourcing partner for pharmaceutical companies
and contract manufacturers worldwide.
Product Description:
Levoketoconazole is an orally available levorotatory enantiomer of ketoconazole, developed for the treatment of endogenous Cushing’s syndrome. It works as a steroidogenesis inhibitor by selectively targeting key enzymes in cortisol biosynthesis, including 11β-hydroxylase (CYP11B1), 17α-hydroxylase/17,20-lyase (CYP17A1), and steroid 21-hydroxylase (CYP21A2). By inhibiting these enzymes, levoketoconazole reduces circulating cortisol levels, helping to normalize hypercortisolemia in patients with Cushing’s syndrome.
Compared to racemic ketoconazole, levoketoconazole is more potent in suppressing glucocorticoid synthesis while being less likely to inhibit cholesterol 7α-hydroxylase (CYP7A1), which may lower the risk of hepatotoxicity. This makes it a safer and more targeted option for long-term management of elevated cortisol. Levoketoconazole is particularly indicated for adult patients with Cushing’s syndrome for whom surgery is not an option or has been unsuccessful. Its oral tablet formulation allows for convenient administration, and treatment requires monitoring of cortisol levels and liver function under medical supervision. This agent provides an effective pharmacological approach to controlling the complications of chronic hypercortisolism.
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