Macitentan Suppliers & Bulk Manufacturers

Available Forms: Tablets

Available Strengths: 10 mg

Reference Brands: Opsumit (USA)

Category: Heart Disorder

Macitentan is available in Tablets and strengths such as 10 mg. Sourced from GMP-certified and ISO-compliant manufacturers, this API meets global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical formulation and commercial manufacturing, Macitentan is supplied in bulk quantities with complete regulatory support including DMF, COA, and MSDS.

Macitentan can be exported to over 30 countries across Asia, Africa, Europe, and Latin America. Flexible packaging, competitive pricing, and a verified supplier network make Pharmatradz a trusted sourcing partner for pharmaceutical companies and contract manufacturers worldwide.

Product Description:

Macitentan is an orally active, non-peptide dual endothelin receptor antagonist developed by Actelion and marketed under the brand name Opsumit. It selectively blocks both endothelin receptor subtypes, ETA and ETB, with a markedly higher affinity for the ETA receptor, which plays a key role in vasoconstriction and vascular remodeling in pulmonary arterial hypertension (PAH). By inhibiting endothelin-mediated pathways, macitentan helps reduce pulmonary vascular resistance and disease progression.

Opsumit is indicated for the long-term treatment of pulmonary arterial hypertension in adults classified as World Health Organization Functional Class II or III. It is used to reduce morbidity in patients with idiopathic or heritable PAH, as well as PAH associated with connective tissue disease or congenital heart disease. Macitentan can be administered as monotherapy or in combination with phosphodiesterase-5 inhibitors. It is available as 10 mg film-coated tablets, taken once daily, and is designed for sustained efficacy and improved tolerability in chronic PAH management.