Protamine Sulfate Suppliers & Bulk Manufacturers
Available Forms: Injection
Available Strengths: 10 mg/mL, 50 mg/mL
Reference Brands: Generic formulations marketed under different names
Category:
Critical Care
Protamine Sulfate is available in Injection
and strengths such as 10 mg/mL, 50 mg/mL.
Sourced from GMP-certified and ISO-compliant manufacturers, this API meets
global pharmacopeia standards (USP/EP/JP as applicable). Ideal for pharmaceutical
formulation and commercial manufacturing, Protamine Sulfate is supplied in
bulk quantities with complete regulatory support including DMF, COA, and MSDS.
|
Technical Specifications & Supply Details
|
| Lead Time |
7 to 60 days (depending on batch size & schedule) |
| MOQ |
As per manufacturer’s batch size |
| COA |
Available with every batch |
| Regulatory Dossier / DMF |
Available upon request |
| Export Documentation |
FSC, COA, Manufacturing License, Product Permission |
| Standards |
IP, BP, USP |
| Certifications |
WHO-GMP, EU-GMP, USFDA (as applicable) |
Protamine Sulfate can be exported to over 30 countries across Asia, Africa, Europe,
and Latin America. Flexible packaging, competitive pricing, and a verified supplier
network make Pharmatradz a trusted sourcing partner for pharmaceutical companies
and contract manufacturers worldwide.
Product Description:
Protamine sulfate is a specialized medication used to reverse and neutralize the anticoagulant effects of heparin. It acts as a specific antagonist to heparin-induced anticoagulation by forming a stable complex with heparin, effectively restoring normal blood clotting. Protamine sulfate is a highly basic, polycationic, low-molecular-weight protein, originally derived from salmon sperm, and is also available in recombinant forms for pharmaceutical use. Its unique mechanism makes it an essential agent in critical care and surgical settings where rapid heparin reversal is required.
Clinically, protamine sulfate is used in cases of heparin or low molecular weight heparin overdose, during cardiovascular surgeries such as cardiopulmonary bypass, and in obstetric procedures when heparin anticoagulation must be neutralized. It is administered intravenously, with the dosage and infusion rate carefully calculated based on the amount of heparin to be reversed and the patient’s clinical condition.
While highly effective, protamine sulfate must be used cautiously due to potential adverse effects such as hypotension, bradycardia, and rare severe allergic reactions. With careful monitoring, protamine sulfate provides rapid and reliable reversal of anticoagulation, making it a critical tool for healthcare teams managing patients in surgery, critical care, and emergency settings.
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